PW03-011 – New Behçet's loci and gene-gene interactions
نویسندگان
چکیده
Methods We used the Turkish collection GWAS genotypes to impute genotypes of 779,000 markers in the GWAS subjects and then evaluated the imputed markers for disease association. We also searched for new disease associated loci by analyzing patients with uveitis and by specifying different genetic models. We replicated the new BD loci in additional Turkish samples (838 cases, 630 controls) and if polymorphic, in Japanese samples (612 cases, 740 controls). Gene-gene interactions were evaluated by testing the significance of a multiplicative interaction term in a logistic regression model.
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